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The research area and duties
The project is part of a project funded by the Swedish Research Council, aiming to clarify the role of cooperative phenomena and hierarchical ordering in striated muscle function in health and disease (e.g. hereditary cardiomyopathies). The project will be carried out in collaboration between A. Månsson and S. Tågerud at Linnaeus University, H. Linke (Lund University, Sweden), D. Rassier (McGill University, Canada) and J.A. Spudich (Stanford University, USA). The focus will be on development of a mouse myotube based expression and purification system for human striated muscle myosin II. The expressed proteins will be used in various in vitro assays including a novel small-ensemble force measurement system, for studies of hypertrophic cardiomyopathy. The work will be performed in Kalmar, but extensive interaction with labs of collaborators is expected. The postdoc, will work in tight collaboration with a PhD student with focus on biochemistry and biophysics of isolated muscle proteins and a postdoc with major focus on a novel force measurement system. Key experimental techniques, in addition to the newly developed expression system, will be fluorescence microscopy and in vitro motility assays. Supporting expertise to assist the development of the expression and purification system exist in house.
Applicants should have a PhD degree in a subject area of relevance for the project (biochemistry, molecular biology, cell biology, biomedical engineering etc.).
Other assessment grounds
Experience of experimental work using mammalian protein engineering and expression systems is a merit including skills like site directed mutagenesis, DNA cloning, large scale mammalian cell culturing, protein expression and purification. Previous studies of molecular motors and/or muscle are judged favorably. In addition, the Post Doc should have a high proficiency in written and spoken English, exhibit high problem solving skills, and have the ability to work independently as well as interact well in a research group.
Location, until further notice
The Department of Chemistry and Biomedical Sciences in Kalmar
Terms of employment:
Full-time, fixed term (2 years), starting as soon as possible after final application date.
For further information:
Please contact group leader: Professor Alf Månsson (firstname.lastname@example.org). See also: http://lnu.se/personal/alf.mansson Head of Department, Päivi Jokela, tel. +46 (0) 480-44 6071, email@example.com Human Resources Consultant, Christian Andersson, tel. +46 (0) 470-70 8506,firstname.lastname@example.org
Applicants should submit a CV, documentation of exams, a copy of their PhD thesis and reprints if available. A short motivation (£1 A4 page, font 12) explaining the desire to work in the current project should be included. This motivation should include citations of recent work by A. Månsson and co-workers. Finally, contact information (phone number and e-mail) for at least two reference persons should be given. Please apply through lnu.se, and go to “jobs and vacancies”. The application has to be registered no later than February 20th, 2017. Mark your application with reference number 2016/6833-2.2.1
Linnaeus University has the ambition to utilize the qualities that an even gender distribution and diversity brings to the organization.
Please apply by clicking on the "Apply" button at the bottom of the ad. The credentials you invoke must be verified with certification and they must be attached digitally in your application. The application and other documents to be marked with the reference number. All documents cited must be received by the University no later than 24.00 on the closing day.