KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.
Third-cycle subject: Biotechnology
It is well known today that over 50% of modern drugs target membrane proteins. The bottleneck in biochemical study of such proteins is the structural diversity of post-translational modifications, particularly the glycosylation. The glycoprotein most often exists as glycoforms; proteins that differ only with respect to the number and/or type of attached carbohydrate moieties. Therefore, considerable effort has been invested in determining the precise biological roles of structurally defined glycoproteins and, as such, has now emerged as an important area of post-genomic research.
The chemical synthesis provides a unique tool to produce the homogeneous glycoprotein. Despite their value, only small number of glycoprotein have been synthesized, and none of these are membrane-bounded protein. Herein, the project aimed to combine Fmoc-SPPS, recombinant protein expression technologies, peptide ligation chemistries, chemoenzymatic glycan transfer and protein folding, for the practical production of homogeneous membrane glycoproteins. Synthetic products will be assembled in nano-disc, which enables the importance of the carbohydrate moieties for the structure and function of a membrane protein to be interrogated for the first time.
The successful candidate will undertake a multi-disciplinary approach to complete the task and will be supervised by Assistant Professor Yves Hsieh. Majority of laboratory work will be carried out in the Division of Glycosciences, at the Dept of Chemistry. There is also a possibility to visit and work at our collaborator’s laboratories within the CBH School at Dept of Biomedical Engineering and Health Systems, or Academia Sinica and KI.
What we offer
To be admitted to postgraduate education (Chapter 7, 39§ högskoleförordningen), the applicant must have basic eligibility in accordance with either of the following:
In order to succeed as a doctoral student at KTH you need to be goal oriented and persevering in your work. In the selection of the applicants, the following will be assessed:
Target degree: PhD in Chemistry
Information regarding admission and employment
Only those who are or have been admitted to third-cycle studies may be employed as a doctoral student. The term of the initial contract may not exceed one year. The employment may be extended for a maximum of two years at a time. However, the total period of employment may not exceed the equivalent of four years of full-time study. Decisions on employment as a doctoral student may not be appealed.
Eligibility, selection and admissions are regulated in antagningsordning till utbildning vid Kungl. Tekniska högskolan and the program description for the doctoral program and current subject syllabus available on KTH's website.
Doctoral students should primarily devote themselves to their own education, but may engage in teaching, research, and administration corresponding to a maximum of 20 % of a full-time position.
You will find contact information for union representatives on KTH's website.
Doctoral section (Students’ union on KTH Royal Institute of Technology)
You will find contact information for doctoral section on the section's website.
Apply for the position and admission through KTH:s recruitment system. It is the applicant’s responsibility to ensure that the application is complete in accordance with the instructions in the advertisement.
Applications must be received at the last closing date at midnight, CET / CEST (Central European Time / Central European Summer Time).
Applications must include the following elements:
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Gender equality, diversity and zero tolerance against discrimination and harassment are important aspects of KTH´s work with quality as well as core values in our organization.
Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.Type of employment: Temporary position longer than 6 months