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Saarland University
2 PhD positions in systems metabolic engineering (m/f)
Saarland University
Saarland University is a modern university within the Saar-Lor-Lux region – a dynamic part of Europe defined by the shared borders between Germany, France and Luxembourg. An international perspective has been a defining feature of Saarland University ever since it was established in cooperation with France in 1948.
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Publicerad: 5 dagar sedan
Sista ansökningsdatum: okt 26
Plats: Saarbrücken, Tyskland
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2 PhD positions in systems metabolic engineering (m/f)


Our expertise – Institute of Systems Biotechnology – iSBio
We are an internationally leading research institute of Saarland University, located in the heart of Europe, close to France and Luxemburg. Headed by Prof. Christoph Wittmann, our team of dedicated scientists works on systems biology, systems biotechnology, and systems metabolic engineering. We design tailor-made cell factories and bioprocesses for industrial applications. We provide cutting-edge technology platforms for systems-wide omics analysis of microbes (including transcriptomics, 13C fluxomics, and metabolomics) and their genomic engineering, highly-equipped bioprocess laboratories for cultivation, as well as software tools for computational biology. Since 20 years, we successfully act as partners in collaborative projects and cooperate globally with universities, research institutes, and industrial companies. Our PhD alumni work in leading research institutes and biotech companies. 

Our offer
We offer 2 PhD positions (TVL E13 50%, fixed term contract 3 years), dedicated to systems metabolic engineering of industrial microorganisms. The positions are open from January, 1 2019. The following topics are available

- PhD position in systems metabolic engineering of industrial microorganisms - Strain engineering (Ref. W1434)

- PhD position in biochemical engineering of industrial microorganisms - Process engineering (Ref. W1435)
Your role
Within the project, you will design and create novel producers to convert renewables into added-value products. A focus will be on the development and application of molecular tools for the soil bacterium Pseudomonas putida. You will then apply these techniques to design and create superior strains (W1434). Another focus will be on the pretreatment and characterization of the lignocellulosic raw material, to be used by the microorganism as substrate. Bioprocess development will be supported by omics analyses, involving collaboration with national and international partners (W1435). You will present and publish the data at international meetings and in high-impact scientific journals. In your work, you will apply the following techniques:

- Genetic engineering of Pseudomonas putida

- Strain characterization in shake flasks and parallelized mini-bioreactors

- Raw material depolymerization and process-related analytics

- Omics analysis, including 13C fluxomics, metabolomics and transcriptomics

- Bioprocess development for newly designed producer strains

Your profile

- Very good master degree in biotechnology, bioengineering or a related field with a solid background in quantitative bioengineering

- Out-going personality and excellent teamwork skills

- High self-motivation and passion for science

- Excellent communication skills; including English language

The next step is yours. Work contract and salary will accord to the respective collective agreement, i.e. TV-L. Saarland University aims to increase the number of women in this field. Therefore, women are encouraged to apply for this position. Physically handicapped persons will be preferred in case equally qualified. We look forward to receiving your online application including a letter of motivation, CV, transcripts, and contact details of 2 referees. Please refer to reference W1434 or W1435 in your application. Closing date for applications is October 26, 2018. Please submit your application as a single PDF file to biotechnologie@uni-saarland.de

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