Doctoral Researcher, Cell and Molecular Biology

We are looking for a Doctoral Researcher at the Department of Biological and Environmental Science, University of Jyväskylä to join the ’Optogenetic Modules’ group of Heikki Takala. The fully funded position for three years will start on 2 January 2025 or as agreed.

Project description

The group of Heikki Takala studies photoreceptor proteins, especially red light-sensing phytochromes, with a special focus on their application for optogenetics.

We are seeking a highly motivated person to develop and apply phytochrome-based optogenetic tools in breast cancer cell models in a PhD project entitled "Red light sensing optogenetic tools and their application for cancer therapy". Phytochromes are photoreceptor proteins that respond to red/far-red light. To study these responses and apply them to optogenetics in this project, activity assays in bacterial and mammalian cells, as well as  biochemical assays with purified protein, will be utilized. The project will develop optogenetic tools that enable red light-induced apoptosis of breast cancer cells (Fig. 1). These tools will be assayed in 2D and 3D cell models for their therapeutic applicability. The project will provide diverse training and experience in the fields of cell and molecular biology, photoreceptor research, and optogenetics.

     Figure 1. The project aims to generate tools for red light-induced

     apoptosis of cancer cells.

Qualifications

Applicants must have a Master’s degree, or be about to obtain a Master’s degree, in cell and molecular biology, biochemistry, or other relevant discipline. Ideal candidates should have a strong interest in cancer cell models, photoreceptor research, and optogenetics. Preliminary experience with molecular cloning and mammalian cell cultures is considered highly advantageous.  A commitment to accuracy and responsible conduct of research is essential. We require strong motivation to write a PhD thesis, excellent collaboration skills, good oral and written English language skills, and ability to work independently in the laboratory.

The duties, qualification requirements and language skills of a Doctoral Researcher are stipulated by the University of Jyväskylä Regulations and language skills guidelines. The MSc degree required for the position must have been completed before starting the position. Doctoral Researcher needs to be also enrolled in the doctoral programme which can be applied from the Faculty of Mathematics and Science after selection for the position.

We offer

• Funding for 3 years in the doctoral program of the University of Jyväskylä.
• Supervision in all aspects of the work, a highly skilled project team and possibility to join workshops to improve specific skills in e.g. bioinformatics, data analysis.
• International, enthusiastic working environment (working language is English) and a large collaborator network
• Excellent research infrastructure at Jyväskylä and state-of-the-art scientific equipment, software, access to journals and scientific databases.
• Resources for travel to conferences or workshops abroad.

The position will be based at the University of Jyväskylä, where the student will join the PhD programme in Biological and Environmental Science. At the University of Jyväskylä, you are a recognized member of our community with an ample opportunity to be drawn into international research. You get to participate in our international and multidisciplinary community, where everybody’s welfare is essential. You will work in an inspiring and lively campus area and an environment that supports a healthy and active lifestyle. 

Finland has a high standard of living with healthcare, free schooling (also in English), affordable childcare, and good family benefits. The city of Jyväskylä is located in central Finland amidst Finnish lakes and has excellent opportunities for different nature, outdoor, and sports activities. It is a major educational center, whose large student population is responsible for a vibrant cultural scene. To find useful information about the University of Jyväskylä, the City of Jyväskylä, and living in Finland, see the University's Handbook for international staff and visitors

The initial annual salary will be approximately 30,000 EUR (gross income, including a holiday bonus). With progress of the thesis work, the salary will be revised in accordance with the Collective Agreement of Finnish Universities. The employment starts with a trial period of six months.

How to apply

The application documents that should be included in PDF format:

1. A two-page long Curriculum vitae, composed according to good scientific practice and considering the template for researcher´s curriculum vitae by The Finnish Advisory Board on Research Integrity and including contact information of two academics who can provide reference letters
2. Max 1-page motivation letter describing your scientific interests and key motivation for applying for this position
3. A numbered list of publications, if any
4. Relevant certificates / diplomas (or date of completion the MSc)

Eligible candidates will be evaluated based on the submitted documents following the recommendations for the responsible evaluation of a researcher in Finland. Shortlisted candidates will be invited for a personal interview. 

For more information, please contact Academy Research Fellow Heikki Takala, heikki.p.takala@jyu.fi.